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The findings that COMP-deficient mice develop severe autoimmune CIA indicate that COMP deficiency makes the cartilage more susceptible to an inflammatory attack.
Furthermore, PEDF deficiency makes the pancreas more prone to fibrosis as PEDF-deficient pancreases display significantly increased basal transcription levels of collagen αI, transforming growth factor β1 and platelet-derived growth factor (PDGF) [ 32].
If revision implants are required to help control the fracture and provide stability, then revision to reverse geometry implants in patients with cuff deficiency makes good sense.
The stringent response deficiency makes cellular metabolism disordered by transcriptional regulators deactivation, and therefore cells are much more unbalanced in a stressful environment.
This awareness deficiency makes it extremely difficult to get robots out of their single-task comfort zone, the authors write, because of the "inherent uncertainty in sensing, control, and contact physics". These are all things human beings take for granted.
This deficiency makes handling email on the iPhone slower and less efficient; it also translates into wasted battery power as users need to perform the extra step of opening the iPhone's email program every time they want to check for new mail.
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Identifying the deficiency made it possible to develop a treatment, an intravenous form of the needed protein.
Presenting his IT deficiency made it impossible for anyone to challenge him as being an industry-outsider — he pre-emptively admitted he was and declared that others needed to oversee IT issues.
Although TopBP1 deficiency made endothelial cells susceptible to DNA damage and apoptosis in response to hydroxyurea, its restoration resulted in less DNA damage and improved cell survival.WES led to the discovery of TopBP1, a gene whose deficiency may increase susceptibility to small vessel loss in IPAH.
On the other hand, the mitochondrial electron transport chain deficiency made the expression of HIF-1α severely reduced, and HIF-1 DNA binding was diminished, which suggested that electron transport chain activity is required for activation of HIF-1 (Agani et al., 2000).
This H-FABP deficiency made the heart intolerant to acute exercise and eventually led to localized cardiac hypertrophy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com