Lumican deficiency resulted in significant (50%) perinatal death and further examination of the lum−/− neonatal hearts revealed an increase in myocardial tissue without a significant increase in cell proliferation.
Akt2 deficiency resulted in significant reductions the weights of EDL and gastrocnemius, whereas the weight of soleus muscle was increased relative to wild-type mice.
Two major effects were observed: ATGL deficiency resulted in significant upregulation of sGC activity and increased levels of BH4.
Iron deficiency resulted in significant and higher than 2-fold changes in the relative amounts of 61 polypeptides, and 22 of them were identified.
While perlecan deficiency resulted in significant decreases in more parameters (such as lacunar volume and the canalicular number density), diabetes impacted only the lacunar density.
Two senior paediatric pathologists say they have discovered vitamin D deficiency in a significant number of children who have died of Sudden Infant Death Syndrome.
Apart from the deficiency in producing significant amounts of transitory starch, adg1-1/tpt-2 is incapable of producing large quantities of soluble carbohydrates during the day.
Kif3a deficiency, however, resulted in significant reductions in adipocyte-related markers, including adipocyte-specific fatty acid binding protein (aP2), lipoprotein lipase (Lpl), and Adiponectin in long bone samples (Fig. 3D).
The mRNA levels of Creb, c-fos, C/EBP, zif268, Bdnf and Syt were dramatically decreased in feeders, which might result in significant deficiency in memory retention of its natural food preference (live prey fish).
Observed heterozygosity (HO) was significantly different from HE in nine locations where heterozygote deficiency was detected, resulting in significant positive values of the inbreeding coefficient FIS (Table 1).
In addition, telomerase deficiency caused significant reduction in IGF signaling proteins in osteoblastic cells cultured from telomerase deficient mice (Terc− / −).
