Deficiencies in methods reporting in animal experimentation lead to difficulties in reproducing experiments; the authors propose a set of reporting standards to improve scientific communication and study design.
The Office of Protection from Research Risks OPRRR), an agency at the National Institutes of Health that safeguards the treatment of patients in research, suspended federal support for clinical studies at Duke on 10 May because it found "severe deficiencies" in methods of filekeeping and protocol review (ScienceNOW, 12 May 1999).
The quantitative measurements confirmed that OCT can be used in primary diagnosis to compensate for the deficiencies in methods of pathological diagnosis, with a great potential for early diagnosis of tissues.
We cannot rule out the possibility that these outliers reflect a deficiency in our method, but for the reasons discussed above, we have excluded them from further analysis.
We demonstrate this approach by using the OPEN Process Framework (OPF) to identify previous deficiencies in the method fragments stored in the OPF repository so that the enhanced OPF repository is able to fully support AOSD.
Results from the experiments and numerical analyses were used to identify deficiencies in existing methods of analysis that uses assumptions of one-dimensional flow, homogeneity of aquifer properties, local equilibrium and idealized transient mass transfer.
We conclude that the claim is almost certainly based on artifactual data resulting from improper determination of the social form of the study colonies, inadequacy of sampling, and/or technical deficiencies in the methods used to assay for GP-9b transcripts and protein.
There are recognised deficiencies in current methods of predicting and limiting complications in PAD patients [ 2, 3].
The potential of this approach has been limited by deficiencies in the methods currently available for random mutagenesis and library generation [ 2].
Unfortunately, the capability of this approach has been restricted by deficiencies in the methods currently available for random DNA mutagenesis and library generation.
13 A review of 83 clinical prediction models in acute stroke, for example, found serious deficiencies in statistical methods in almost all of the studies; in addition, none of the studies had been adequately validated.
