Sentence examples for deficiency in function from inspiring English sources

These observations suggested that deficiency in function of the newly identified BH4-dependent enzyme AGMO might explain the hypersensitivity and cuticle fragility phenotypes of cat-4 and ptps-1 mutants.

This is highly relevant since a number of genetic disorders characterized by genomic instability and/or sensitivity to agents that impose DNA damage or replication stress are attributed to deficiency in function of a gene that encodes a protein that may affect the formation or stability of G-quadruplexes.

But that assumption is based on testing kidney function by measuring serum creatinine levels, a measure too crude to pick up subtle deficiencies in function.

The TRAF6-RelB deficient mice provide striking examples of how an apparent immune deficiency – in NFκB function – can also cause autoimmunity.

We previously reported that reduction of TR1 levels in cancer cells reversed many malignant characteristics suggesting that deficiency in TR1 function is antitumorigenic.

This is a categorization reflects the fact that low MMR protein expression levels (<10%) are required for a deficiency in MMR function [28].

Further investigations are needed to detail the mechanism underlying the reversal in putrescine-induced deficiency in DC function.

For many years, researchers have been struggling to identify the mechanism that causes the deficiency in PTEN function.

A deficiency in peroxisomal function has been suggested to cause oxidative stress (Baumgart et al., 2001; Bonekamp et al., 2009).

Second and more importantly, it raises the rationale for targeting cancer subtypes with a deficiency in HR function [1].

Interestingly, we showed in the present study that in vitro treatment of DCs with ATRA could reverse the putrescine-induced deficiency in DC function.