Sentence examples for deficiency in factor from inspiring English sources

Hemophilia A, caused by a deficiency in factor VIII (FVIII), is the most severe inherited bleeding disorder.

However, the demerits of this assay includes its reduced sensitivity in the presence of platelet poor plasma and its incapability to detect mild deficiency in factor VIII (Chitlur and Simpson 2015).

Although recombinant factor VIIa has been shown to bypass the deficiency in factor VIII or factor IX, efforts to reduce factor consumption and subsequently treatment cost have been focused on continuous infusion regimens with variable success.

Point mutations in these TFBSs are known to lead to various forms of hemophilia B: mutations in the C/EBP and HNF-4 sites lead to hemophilia B Leyden; mutations in the AR site lead to hemophilia B Brandenburg, characterized by a life-long deficiency in factor IX [ 14].

Studies over the last several decades have demonstrated that a complete deficiency in factors mediating antibacterial response results in severe mycobacterial infections [4] [6].

We report that in F2 mice the major characteristics of progressing TB was not the number of mycobacteria growing in the lung, or a deficiency in factors supporting antibacterial immunity.

Additional investigations revealed blood clotting disturbances, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), deficiency in factors XI XII, elevated transaminases, hypoproteinemia, anaemia (Hb 7,3, E 2,97), thrombocytopenia and nodular changes in the liver.

In general, the greater the deficiency in either factor VIII or factor IX, the more severe the manifestations of disease.

Deficiencies in factors that regulate the DNA damage response enhance the incidence of malignancy by destabilizing the genome.

Deficiencies in factors involved in ribosome synthesis have been studied extensively in Drosophila, Xenopus, zebrafish and mouse (Danilova et al., 2008; Kongsuwan et al., 1985; McGowan et al., 2008; Miller and Gurdon, 1970).

Lowther et al. reported that disruption of endoplasmic reticulum during vitrification of mouse oocytes and deficiencies in factors involved in endoplasmic reticulum reorganization during oocyte maturation could contribute to the low development potential of vitrified in vitro-matured oocytes [ 49].