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Our analysis of genetic models with a wide range of systemic S1PL deficiency extend on these studies and clearly demonstrate that T-cell trafficking is particularly tightly controlled by S1PL activity compared to other physiological processes.
Effects of Vitamin A deficiency extend much beyond blindness alone.
Clinical manifestations of ADA deficiency extend beyond the immune system (deafness, behavioral problems, cognitive deficits, gait abnormalities, costochondral abnormalities, and liver toxicity), reflecting the fact that ADA is a housekeeping enzyme.
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This deficiency extends to such socially important visual stimuli as people's faces.
Ap4 deficiency extends their average survival by 110 days and decreases the formation of intestinal adenomas and tumor-derived organoids.
Additionally, prohibitin deficiency extends the lifespan of nhr-49 mutant.
Prohibitin deficiency extends the lifespan of both nhr-49 and fat-7 mutants [ 17].
Prohibitin depletion results in reduced fat content, in all genetic backgrounds where PHB deficiency extends lifespan [ 17].
Interestingly, it was found that prohibitin deficiency extends the lifespan of both nhr-49 and fat-7 mutants [6].
Prohibitin deficiency shortens the lifespan of p53 (cep-1) mutant animals, however, it would be necessary to examine the requirement of p53 in the cases where PHB deficiency extends lifespan.
The clinical spectrum of antiquitin deficiency extended from ventriculomegaly detected on foetal ultrasound, through abnormal foetal movements and a multisystem neonatal disorder, to the onset of seizures and autistic features after the first year of life.
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