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A similar effect of tapasin deficiency decreasing peptide number has recently been reported for the mouse MHC I molecule H-2Db and Kb (Kanaseki et al., 2013).
TAPBPR depletion and tapasin deficiency produced different effects on peptides presented by HLA-B40 and -C03 in IFN-γ treated KBM-7 cells, with TAPBPR depletion increasing peptide diversity and tapasin deficiency decreasing the number of peptides presented.
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A second independent study on LGP2-deficient mice, however, reported that LGP2 deficiency decreased cytokine responses to infection with several RNA viruses [24].
The latter may be caused by Fe deficiency decreased active Fe content.
We found that LRRK2 deficiency decreased the level of phosphorylated Rip2 upon thapsigargin treatment (Fig. 7D).
berghei IgG enhanced parasite growth and C3 deficiency decreased parasite growth in mice.
Ces1g deficiency decreased PUFA release from TG, which consequently caused sustained SREBP1c activation and increased de novo lipogenesis in the liver (Quiroga et al., 2012a) (Fig. 4).
Estrogen deficiency decreased glomerular estrogen receptor expression in ROP Os/+ mice, which we had previously found to be low in the parental ROP strain.
We found that N deficiency decreased Fv/Fm, REo/ETo, ETo/ABS, Sm, ETo/CSo, PIabs, PItot, abs (Fig. 7A, B) and increased DIo/CSo, DIo/RC and DIo/abs (Fig. 7C).
Copper (Cu) deficiency decreases the activity of Cu-dependent antioxidant enzymes such as Cu,zinc-superoxide dismutase (Cu,Zn-SOD) and may be associated with increased susceptibility to oxidative stress.
These conditions can cause androgen deficiency, decreased libido and decreased quality of life.
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