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Due to constant deficiency compensation processes of the recessive dystrophic EB cell line [ 43], other physiological activities could be limited.
The high transcript levels of two cytochrome P450 genes, involved in polyphenol synthesis, in Mo17 at both iron regimes points to an iron deficiency compensation response (Additional file 1: Figures S7 and S10).
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They want reasonable compensation".
While we did not measure arterial flow through these iron deficient arteries, the enhanced inotropic compensation to iron deficiency, combined with the enlarged aortic diameter, leads us to suspect a flow dependent mechanism for remodeling.
Genes of the second type tend to have low overall expression or be expressed ubiquitously, demonstrate little compensation for deficiency and greater compensation for duplication.
Therefore, DC and HHS have been regarded primarily as telomerase-deficiency diseases, where insufficient compensation for telomere shortening impairs cell proliferation, and the disease manifests particularly in tissues with a high turnover [33].
Daily compensation of the deficiency requires 4 6 insulin injections to be taken daily, the aim of this insulin therapy being to maintain normoglycemia – i.e., a blood glucose level between 4 and 7 mmol/l.
There was a second feature of the data which appeared to indicate gestural compensation for semantic deficiency in verbal language.
The possibility exists that upregulation of the functionally relevant paralogues reflects a compensation for a deficiency of TMEM106B in AD brains.
The former types of genes tend to: 1) have high overall expression or be expressed in a tissue-specific manner, 2) demonstrate a stronger dosage compensation for a deficiency, and 3) demonstrate little dosage compensation for duplication.
The experiment showing increased survival in animals administered the anti-RAGE antibody confirms that the benefit is present in situations in which physiologic compensation for genetic deficiency could not have occurred.
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