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The mechanisms responsible for this phenomenon are not identified but it is tempting to speculate that i) the higher differentiation capacities of MSCs in osteoblasts in the absence of ERRα as well as ii) the low expression of opn in ERRαKO osteoblasts could be involved in sparing bone under estrogen deficiency challenge.
These stressors, together with other weaknesses such as physiological unbalance or nutritional deficiency, challenge homeostasis and thus allow opportunistic infections to proceed [ 1].
However, pleiotropic phenotype derangements induced by calreticulin deficiency challenge the identification of specific downstream transcriptome elements that direct proper cardiac formation.
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It is simple, economic, and does not suffer the now mounting deficiencies challenging thermal cracking theory.
Everywhere I look there's another article, about millennials, written by a member of an older generation, pointing out our deficiencies, challenges, and problems.
We know that Tim will be in the hands of a woman who really loves him and also one who will accept his deficiencies and challenge him where she knows he can grow.
Revision arthroplasty for failed post-traumatic humeral head replacement associated with rotator cuff and glenoid deficiency is challenging.
However, rapid diagnosis of PDH deficiency is challenging as it is often not possible to separate it from other mitochondrial disorders by mere clinical observation and specific metabolites/biochemical findings [2].
Practical considerations, hazard complexity, exposure complexity, and regulatory deficiencies all challenge the naivety of this assumption.
Identifying the plethora of mutations responsible for complex I deficiency is challenging but essential for providing accurate and helpful diagnostic counselling.
The idea that oedematous malnutrition was caused by dietary protein deficiency was challenged when studies from India and Nigeria found no difference in dietary protein between children with oedematous and non-oedematous malnutrition [ 23, 32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com