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Furthermore, APN deficiency augmented high fat diet-induced upregulation in the autophagy adaptor p62 and the decline in AMPK without affecting high fat diet-induced decrease in LC3II and LC3II-to-LC3I ratio.
In the present study, AT2R deficiency augmented pressor responsiveness to AngII in adult female mice.
In lean mice, TNFR2 deficiency ablated O3-induced AHR without affecting pulmonary inflammation; whereas in obese mice, TNFR2 deficiency augmented O3-induced AHR but reduced inflammatory cell recruitment.
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Mice on the iron deficient diet also had a shorter latency to onset of seizures and a longer mean duration of seizures and post-ictal period, suggesting that iron deficiency augments the effects of lead toxicity in mice [31].
These results indicate that CHL1 deficiency augments the ventilatory response to AH.
Local and systemic antithrombin and APC deficiencies augment the proinflammatory response and thereby contribute to increased leukocyte endothelial-cell interactions and capileukocyte endothelial-cell
In 51 cases (31%), the proximal femoral deficiency was augmented by cancellous autograft and/or allograft.
Our results have shown that EP2 deficiency in MCs augmented COX2 and mPGES-1 expression stimulated by TGFβ1, whereas EP2 over expression decreased their expression.
Here, we address these deficiencies by augmenting endothelial cell transplantation with dual delivery of vascular endothelial growth factor (VEGF) – to improve survival of transplanted EC – and monocyte chemotactic protein-1 (MCP-1) – to induce mural cell recruitment.
EP2 deficiency in these MCs augmented FN (fibronectin), Col I (collagen type I), COX2 (cyclooxygenase-2), mPGES-1 (membrane-associated prostaglandin E1), CTGF (connective tissue growth factor) and CyclinD1 expression stimulated by TGFβ1.
For Mullins, the discussion is no longer about compensating for a deficiency, but about augmenting the body.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com