In comparison, the only gene down-regulated by Se-deficiency and overlapping with these Nrf2 datasets was thioredoxin reductase-1 in mouse liver (Table 2).
One recent study used an existing allele with a P-element insertion in an intron within the Dcas coding region, and a deficiency mutation overlapping Dcas and 5 adjacent genes, to establish a modifier role for Dcas in axonal fasciculation and axon guidance [40], but did not address the question of any potential early embryonal phenotypes.
These challenges are manifold and overlapping.
For 12 of the parent interacting deficiencies, overlapping deficiencies were not available.
These data indicates that the induction of anthocyanin production by exogenous sucrose and phosphate deficiency are overlapped but distinguishable.
However, they are protected from malaria to some extent, and it is well known that the worldwide map of high prevalence of G6PDH deficiency largely overlaps with malaria prevalence.
To test whether the gyc76C allele is a null allele, we analyzed embryos trans-heterozygous for gyc76C and two overlapping deficiencies that delete the entire gyc76C gene, Df 3L fln1 and Df 3L XS533 (Table 1).
Smaller and partially overlapping deficiencies in 12 of the 32 chromosomal regions were checked for their ability to modify the Zfrp8 null/+ phenotype.
This conclusion is supported by the finding that dwarfism and CR may impact lifespan through independent mechanisms [19], and the finding that GH deficiency and CR display minimal overlap at the gene expression level [20].
Our model in no way established a causal link between anabolic hormone deficiency and PD; these conditions might simply overlap and they have probably separate pathophysiologic pathways.
3 The facts that the geographical distribution of malaria and G6PD deficiency is shown to overlap and that Plasmodium-infected subjects, therefore, might be exposed to high doses of 8-aminoquinolines highlight the need to assess the status of G6DP in the population to ensure the safe use of these drugs.
