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Vitamin B12 and folate deficiencies were defined as levels below 191 ng/L [ 20] and 2.5 μg/L [ 21], respectively.
Protein C and S deficiencies were defined as activity levels of <65% of the level measured in normal pool plasma.
Severe or partial GH deficiencies were defined as a peak GH below 3 μg/l or between 3 and 5 μg/l, respectively, after stimulation with GHRH.
Iron, vitamin B12, and folate deficiencies were defined as plasma ferritin, cobalamin, and folate concentrations <15 ng/mL (15), <150 pmol/L (16), and <7 nmol/L, respectively (17).
Similar(56)
Formal deficiencies are defined as a mismatch of the applied method and the method required by IQWiG and G-BA.
Methodological deficiencies are defined as an inappropriate methodology of the indirect comparison, as for example heterogeneity of study results within MTC, non-similarity of studies, inconsistencies of outcomes of comparisons.
Lower reference limits for anemia and Cbl deficiency were defined according to Danish reference limits.
Vitamin D [25(OH D] insufficiency, deficiency, and severe deficiency were defined as <30, <20, and <15 ng/mL, respectively (20, 21).
Vitamin D sufficiency, insufficiency, and deficiency were defined as serum 25(OH D concentrations (nmol/L) > 75, < 50, and < 25, respectively [ 21].
18 Because ferritin and RBP are acute phase proteins, iron deficiency and vitamin A deficiency were defined using a correction factor approach to adjust ferritin and RBP values for the presence of inflammation, as described previously.
Testosterone deficiency is defined, variously, as below 220 to 350 nanograms of testosterone per decilitre (ng/dL) of blood serum.
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CEO of Professional Science Editing for Scientists @ prosciediting.com