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Formal deficiencies are defined as a mismatch of the applied method and the method required by IQWiG and G-BA.
Methodological deficiencies are defined as an inappropriate methodology of the indirect comparison, as for example heterogeneity of study results within MTC, non-similarity of studies, inconsistencies of outcomes of comparisons.
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Vitamin B12 and folate deficiencies were defined as levels below 191 ng/L [ 20] and 2.5 μg/L [ 21], respectively.
Protein C and S deficiencies were defined as activity levels of <65% of the level measured in normal pool plasma.
Severe or partial GH deficiencies were defined as a peak GH below 3 μg/l or between 3 and 5 μg/l, respectively, after stimulation with GHRH.
Iron, vitamin B12, and folate deficiencies were defined as plasma ferritin, cobalamin, and folate concentrations <15 ng/mL (15), <150 pmol/L (16), and <7 nmol/L, respectively (17).
Testosterone deficiency is defined, variously, as below 220 to 350 nanograms of testosterone per decilitre (ng/dL) of blood serum.
Glutamine deficiency was defined as a plasma glutamine level of less than 420 µmol/L.
TSH deficiency was defined as T4 l < 11.5 pmol l and TSH < 4.2 mUI l.
Vitamin D deficiency was defined as a 25-hydroxyvitamin D level below 20 ng/ml (50 nmol/L) and vitamin D insufficiency as a 25-hydroxyvitamin D level of 21 29 ng/ml (52.5 72.5 nmol/L) [30].
Iron deficiency was defined as a sTfR/log ferritin index of 5.6 or more [9], [10].
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