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Samples were randomly allocated to immediate testing and treatment for chlamydial infection, or storage and analysis after a year (deferred screening controls).
Baseline characteristics of participants were similar between the screened and deferred screening groups except that more women in the screened group reported symptoms in the six months before recruitment (table 1).
Vaginal swabs from packs allocated to deferred screening were stored at −80°C and analysed one year later.
Seven of 74 women in the deferred screening group developed clinical pelvic inflammatory disease (incidence 9.5%, 4.7%too 18.3%).
In 137 women with chlamydial infection at baseline, 9.5% in the deferred screening control group developed pelvic inflammatory disease compared with only 1.6% in the screened group.
The rate of independent testing reported by women in the deferred screening group who were positive for chlamydia at baseline was even higher (43%).
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"Power of me" folks, on the other hand, believe in the power of prevention and may defer screening tests until their age puts them into a high risk group.
However, efforts to coordinate return visits to re-screen women with unsatisfactory cytology often fail (McGarahan and Smith-McCune, 2005), and presumably, deferring screening for women who present near the time of menses would present similar problems.
Seventy-one (9.5%) candidates were deferred by means of the screening questionnaire.
To provide accurate information to families at the optimal time to facilitate decision-making for important life events (e.g. school choices, deferred or delayed school entry), screening and assessment for developmental disorders (e.g. Autism Spectrum Disorder), and monitoring for less visible medical conditions (e.g. hypertension).
In the Prevention of Pelvic Infection (POPI) Trial (11), participants in one arm were screened and treated immediately, while in the other arm screening and treatment were deferred until the end of the study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com