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Giri forced an early trade of queens, perhaps believing that would lighten his defensive burden, but Kramnik had no trouble gaining an advantage.
But at least Mauricio Pochettino has now taken steps to mitigate the problem, switching to a back three and lightening the defensive burden on full-backs better going forwards than backwards and his only players likely to beat a man on the outside.
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This approach can put a heavy burden on defensive backs, particularly outside corners.
Still, it's uncommon to see a Cover 2 defense be done in by poor secondary play; it's a zone scheme that naturally lifts much of the burden off defensive backs.
Still, despite a series of trials that have put Mr. Obama on the defensive and illustrated the burdens he might carry in a fall campaign, the Obama campaign is rolling along, leaving Mrs. Clinton with dwindling options.
Critics point to defensive medicine as the hidden burden that liability imposes on health care.
If an opposing quarterback has all day to throw the ball, it places a tremendous burden on the defensive backs to cover longer – and this group has trouble covering in the first place.
In this hypothesis, increased or "hyper" phosphorylation of MAPT is not the driving force of toxicity, but rather a cellular defensive mechanism to alleviate the burden of "hyperbound" MAPT disrupting microtubule trafficking.
Aiding this cause is that Juan Castillo's new defensive scheme places an extra heavy burden on linebacking.
In this terminal phase of infection, the cells seem to be unable to maintain a defensive response to the increasing ROS burden, with a higher density of these aggregates appearing in apoptotic cells.
The presence of Gareth Barry and Scott Parker meant that the creative trio needed to spend little time worrying about defensive duties, while Barry and Parker were not burdened with the need to show imagination.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com