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The phrase "defend their interests" is grammatically correct and can be used in written English.
It means to protect or advocate for one's own needs or desires. Example: The labor union is fighting to defend their interests and secure better working conditions for their members.
Exact(60)
They won't take casualties to defend their interests.
The rich will always mobilise to defend their interests.
Corporations can use the courts to defend their interests.
She says she is helping to ensure both sides can defend their interests.
It suggests that to assert control and defend their interests, authorities may demonise the victims of disaster.
The idea is to signal to Shiite Iran that the Sunni Arab monarchs will defend their interests, analysts said.
If not, they will cut their own deals with various power brokers to best defend their interests.
In the aftermath of disasters, they all vigorously defend their interests, and rarely are any of them held accountable.
In past elections, Malay voters have opted for parties or coalitions that pledged to defend their interests.
Paradoxically, the Communist victory wound up eliminating the freedom of workers to come together in associations to defend their interests.
The question I seek to explain is the mobilisation of discourses of stewardship by farmers to promote and defend their interests in this debate.
More suggestions(17)
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maintain their interests
defend their businesses
are their interests
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safeguarding their interests
champion their interests
advocate their interests
upholding their interests
represent their interests
protect their interests
defence of its interests
to protect its interests
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preserve its interests
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com