Sentence examples for defects underlying from inspiring English sources

Myocardial copper deficiency and defective cellular copper transport/trafficking are revealed as key molecular defects underlying LV impairment in diabetes, and TETA-mediated restoration of copper regulation provides a potential new class of therapeutic molecules for DCM.

The genetic defects underlying ocular albinism result in the growth of abnormally large melanosomes (called macromelanosomes); melanosomes are the structures that normally synthesize and store melanin.

Better understanding of the biochemical defects underlying hereditary skin disorders now allows these conditions to be diagnosed with more precision.

The ultimate role for allo-HCT in the treatment of autoimmune disease will be better defined by results of ongoing auto-HCT trials, and by an improved understanding of disease pathogenesis, the genetic defects underlying different forms of autoimmune disease, and the mechanisms by which HCT may tolerize memory T and B cells.

Search for mutations in ion channels expressed in the central nervous system may help in finding defects underlying some of idiopathic epilepsies, thereby enhancing, our understanding of the molecular pathogenesis of epilepsy.

Much progress has been made in elucidating gene defects underlying disease, in understanding mechanisms leading to disease, and in designing molecules for translational research and gene-based therapy to interfere with the progression of disease.

The scientists are now screening infertile women to see whether Juno defects underlie their condition.

Our conclusion is that, rather than fully formed structures, the primary targets of Cdc42′s action are the apical adherens junctions and cortical actin cytoskeleton in immature supporting cells, and that these developmental defects underlie the inability for normal wound healing.

The increasing awareness that ciliogenesis defects underlie many human pathologies has further increased the desire to fully characterize the structure and function of these fascinating organelles [19].

Our goals were to investigate whether TUBB mutations and mismatch repair defects underlie paclitaxel and cisplatin resistance.

While many of the genes involved in ciliogenesis remain to be identified, it is evident that ciliary defects underlie a significant number of developmental human disorders (Baker and Beales, 2009).