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The main findings from our study indicated no increased incidence of congenital birth defects in the study population, which consisted of women who had used Canephron® N during the first trimester of pregnancy.
Despite the relevance of this study to a low resource setting, we noted some inherent defects in the study.
Because of the rarity of specific birth defects in the study population, birth defects were aggregated into three general groups.
A potential limitation of our study was that there were no cortical defects in the study femurs.
A recently developed statistical spatial method for detecting hotspots, Getis's [ 7], was used to detect the high-risk regions for neural-tube birth defects in the study area.
Furthermore, the high prevalence of enamel hypoplasia in the study population [ 20] makes it imperative to further explore the prevalence of other enamel defects in the study population such as MIH and DMH, which may also increase the risk for caries just like enamel hypoplasia [ 21].
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Since there are also profound differences between mice and humans regarding adaptive and innate immune functions in general (Mestas & Hughes, 2004; Seok et al, 2013), it is apparent how model systems might not always reflect the situation in patients who have defects in the studied genes.
For the remaining bone measurements, Student's t test revealed a statistically positive difference in the measurements carried out from the CEJ to the base of the bone defect, and the width of the bone defect in the study group (to a level of probability of 95%).
An SAE is defined as any life-threatening medical event that may require medical or surgical intervention to prevent hospitalization, disability, or a congenital anomaly/birth defect in the study subject or death.
The researchers related the birth defects found in the study with the body mass index of mothers.
The varied presentation of lamellar macular defects presented in the study shows the wide clinical spectrum of macular disorders that may simulate a macular hole on clinical examination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com