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Homozygous Nrp2 mutant embryos exhibit selective defects in the formation of lymphatic vessels, while their veins and arteries form normally.
Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
Defects in the formation of these neurons during development can lead to mental retardation, and during aging or in diseases such as Alzheimer's, there is a decline in cognitive function, particularly memory.
The role of point defects in the formation of surface relief and in the initiation of a fatigue crack in crystalline materials is analyzed.
Although ADNP is associated with heterochromatin3, it has been unclear whether this interaction is relevant to the traits seen in ADNP-deficient mouse embryos — which include defects in the formation of the structure that gives rise to the brain and spinal cord, and aberrant expression of genes normally expressed in the extra-embryonic cells that support embryo development4.
The functional suppression of VND6 and VND7 causes defects in the formation of vessel elements (Kubo et al. [2005]; Yamaguchi et al., [2008]).
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Limb muscles of E12.5 and E14.5 Col25a1−/− embryos show a clear defect in the formation of multinucleated myofibers.
Indeed, an additional deficiency of E2A in Id2 −/− mice rescues a defect in lymphoid tissue inducer (LTi) cell development as well as a defect in the formation of secondary lymphoid structures (Boos et al., 2007).
If you find you pee at a skewif angle and coat your jeans in piss, you may have had a defect in the formation of your urethra, so the opening normally at the glans or tip of the penis is in slightly the wrong position.
In addition, there was no obvious defect in the formation of the peripheral nervous system in these embryos.
The moc1 mutant plants have only one main culm without any tillers because of the defect in the formation of tiller buds [1].
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