Sentence examples for defects in the establishment from inspiring English sources

Furthermore, spontaneous network activity and high-resolution brain imaging revealed defects in the establishment of neuronal networks at very early developmental stages, further confirmed by an unbalanced excitatory and inhibitory network.

Head, brain and craniofacial dysmorphisms point to defects in the establishment of body plan symmetry [22], [28].

We here evaluated whether Te-0 resistance may result from defects in the establishment of compatibility.

This result suggested that disruption of germ cells migration results in defects in the establishment of the initial (neonatal) SSC niche, eventually leading to impairment of SSC function.

In rice, a mutation in SHOOTLESS2 (SHL2) causes defects in the establishment of anther adaxial/abaxial polarity (Toriba et al. 2010).

This study raises the possibility that defects in the establishment of brain lateralization could indeed be causative of cognitive or other symptoms of brain dysfunction.

Although there was no obvious defect in the establishment of cell polarity to account for the abnormal phenotype observed in N1-KD and N4-KD cell cysts in these experiments, this does not rule out a more subtle deficit in the precise timing of TJ or polarity formation which may impair the development of proper epithelial architecture in this 3D system.

In those studies, defects in the early establishment of apical structures were shown to result from disturbances in the Cdc42-dependent Par/aPKC polarity complex, leading to defects in endocytosis-mediated turnover of junctional proteins.

Finally, systematic differences between hESC and iPSC epigenomes may arise through the incomplete erasure of marks characteristic of the somatic cell type of origin (somatic memory) during iPSC reprogramming, or defects in the re-establishment of hESC-like patterns in iPSCs, or as a result of selective pressure during reprogramming and the appearance of iPSC-specific signatures [ 90, 98].

Early defects are observed in the establishment or maintenance of midline structures, such as the notochord and the floorplate, and later defects include absence of distal limb structures, cyclopia, absence of ventral cell types within the neural tube, and absence of the spinal column and most of the ribs.

Knockout of Rspo3 causes defects in the remodeling and establishment of placental and yolk sac vasculature in mice, leading to embryonic death around E10 [52], [52].