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Teratogenesis is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus.
It turned out to cause defects in the developing foetus and around 10,000 babies were born around the world with stunted arms or legs or, in some cases, no limbs at all.
Preconception care also includes certain dietary recommendations, such as supplementation with folic acid to prevent neural tube defects in the developing fetus, and control of existing medical problems (e.g., diabetes) in the mother.
Isoflurane exposure leads to neuronal apoptosis, and subsequent learning and memory defects in the developing brain.
Grain products in the United States are now "fortified" with folic acid to reduce the incidence of neural tube defects in the developing fetus.
Myc null mice die around E10.5 due to major defects in the developing vasculature [59].
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Importantly, the migration defect in the developing cortex is specific to excitatory pyramidal neurons.
In mice lacking both EphB1 and EphB2, we found a localized cell migration defect in the developing CA3 subfield of the hippocampus, which is involved in the rapid encoding of contextual memory.
Consistently, pk1a knockdown leads to neurite outgrowth defects in the retina, similar to defects observed in the developing fly nervous system (Tao et al., 2011).
To gain insight into the molecular mechanisms underlying the proliferative defects observed in the developing palate and skin, we compared gene expression profiles of mutant and wild-type cells or tissues derived from E14.5 skin, E18.5 epidermis and newborn primary keratinocytes.
The most striking defect was observed in the developing liver, occupying only a small fraction of the abdominal areas (Fig. 2C and D).
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