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In addition, we report extensive alternative splicing defects in the brains of BPD subjects compared to controls.
Interestingly, we found no major structural ciliary defects in the brains of these mice.
This suggests that αB-crystallin may be an early indicator of protein misfolding defects in the brains of transgenic mice.
The transgenic mice (mutPOLG Tg mice) harbor mtDNA defects in the brains, which show altered activities of serotonin and noradrenalin.
Advances in MRI imaging techniques have identified a variety of white matter defects in the brains of TSC patients (58, 59).
In this study, we focused upon the frontal and occipital parts of the cerebral cortex, particularly because the frontal cortex region is known to exhibit apparent anatomical defects in the brains of schizophrenia patients [ 22, 23].
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Indeed, a recent study showed that lamin B2 knockout mice have severe defects in the brain resulting from defective neuronal migration during development (Coffinier et al., 2010).
"There were defects in the brain.
There is strong evidence that genetics play a role, and that defects in the brain of children on the autism spectrum occur during pregnancy.
These contactins have distinct but overlapping patterns of brain expression, and null-mutation causes subtle morphological and functional defects in the brain.
Some hypotheses focus on constitutional defects in the brain's various neurotransmitter systems, such as the adrenergic, cholinergic, dopaminergic, and serotonergic systems.
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