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Indeed, mice deficient in TRPM8 [8]–[10] display pronounced defects in responses to pharmacological "cooling" agents and cold at both cellular and behavioral levels, illustrating that, in mammals, this channel plays a physiologically relevant role in the detection of environmental temperature.
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Atomic scale computer simulation of a model of the h.c.p. metal α-titanium is used to investigate the mobility of interfacial defects in response to applied shear stress.
In contrast, both egl1 ctf7 and rad24 ctf7 double mutant cells exhibited synergistic growth defects in response to MMS (Figure 6).
Nevertheless, extracellular KS may also be affected, secondary to amelioration in KS turnover and trafficking defects, in response to lysosomal clearance by rhGALNS.
Mice deficient of FHL2 display defects in response to divers stimuli, including cardiac hypertrophy under β-adrenergic stimulation, healing defects in skin and intestinal wound and attenuated neovascularization after corneal injury [19] [22].
Next, we evaluated whether CD19+CD24hiCD38hi and CD19+CD5+CD1dhi B cells also exhibit cell-intrinsic defects in response to CD40 stimulation.
In S. cerevisiae, only CK2β mutants show adaptation defects in response to DNA damage and this defect is independent of the catalytic CK2 subunits (Toczyski et al. 1997).
The defects in response to β2 AR or α7 nAChR stimulation or quantity in the spleen lead to the dysfunction of inflammation resolution and postoperative cognition decline [ 28].
In both human and mouse studies, for example, there is considerable individual and strain variation in enamel defects in response to a standardised fluoride intake.
Studies of isolated islets show that insulin release defects in response to glucose are associated with impairments in KATP channels and intracellular calcium flux [ 31].
The DCs and macrophages of mice deficient either in TLR2 or TLR9 also showed significantly greater defects in response to IL-12.
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