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These defects are lethal for embryos at day 10.5.
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In animals, all known GPI-anchor related defects characterized by a complete lack of GPI-anchored proteins are lethal for the embryo.
This can be lethal for a performer.
The null mutant of NS5 MTase is lethal for virus.
Null mutants of AtDCL1 exhibit pleiotropic developmental defects and are lethal due to loss of accumulation of miRNAs.
Two genes are synthetically lethal (SL) when defects in both are lethal to a cell but a single defect is non-lethal.
Knockout mutants for PDGF-B, PDGF-Rβ, and PDGF-Rα are lethal due to defects in embryonic development [ 39].
Only homozygous Elovl4-null and Elov4 knock-in mice are lethal due to epidermal permeability barrier defects.
However, these lines are lethal and show also an ER localisation, which might indicate a defect in trafficking.
Leadoff walks are lethal.
Skateboards are lethal weapons.
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