Sentence examples for defective substitute for from inspiring English sources
In both articular chondrocytes and meniscal chondrocytes, FGF-2 alters the ratio between type II and type I collagen, thus possibly resulting in the formation of fibrocartilage, a defective substitute for healthy hyaline cartilage [ 12, 13].
Depending on the type of disease, this can be achieved either by delivery of a functional, therapeutic gene as a substitute for the defective or missing endogenous counterpart or by reducing the levels of a harmful defective gene product, using various sophisticated tools including naked oligonucleotides, viral and non-viral vectors.
One scenario, recently suggested by Dietschy and colleagues, places CD directly in the E/L system of neurons in Npc1−/− mice where it may act as a substitute for the defective NPC1 protein [19].
Due to their defective ATPase activity, these mutants cannot substitute for loss of Kar2p but they complement yeast bearing a C63A mutant, which cannot be modified in response to hyper-oxidation of the ER by ERO1*, as well as wild-type Kar2.
In contrast, the dimerization and membrane binding defective Nup53 mutant (1 320 F172E/W203E) was unable to substitute for the endogenous protein in NPC formation.
Defective H3K4 demethylation at any stage in the germline cycle could substitute for the inefficient maintenance of the mark; that is, H3K4me levels would remain high.
The Nup53 mutant defective in RRM dimerization, which showed reduced membrane binding, was unable to substitute for the endogenous protein in nuclear assembly.
Spain could substitute for Gujarat.
5 Substitute Marco Amelia An early substitute for Abbiati.
"A tolerable substitute for beer".
