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Moreover, our data indicate that BMMCs with reduced total polyamine content exhibit aberrant secretory granules, accompanied by defective storage of histamine, decreased levels of serotonin and an increased content of β-hexosaminidase.
Impairment of insulin signaling in adipose tissue leads to increase of lipolysis and, possibly, defective storage of FFA in adipocytes.
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These findings suggest that the lipodystrophies and T2DM share a state of defective triglyceride storage in adipose tissue, accompanied by ectopic accumulation of lipid in muscle and liver, contributing to insulin resistance and other abnormalities associated with cardiometabolic disease (15).
A possible intriguing hypothesis is that the loss of function of the DAZ gene, the most important gene disrupted by AZFc deletions [ 16], leads to a pathogenic defective mRNA storage.
In that case this court permitted a cause of action in strict products liability against a defendant who supplied a defective tank for storage of gas sold to the plaintiff.
Mutants of glp-1 were shown to exhibit decreased fat storage, defective germline proliferation, and increased autophagy levels [ 68– 70].
We previously reported that loss of function of SigR1 increases IP3-mediated ER calcium release and defective ER calcium storage.
The primacy of defective subcutaneous fat storage versus visceral fat enlargement in the development of metabolic complications is supported by evidence in patients with total lipodystrophy, who experience severe insulin resistance despite the lack of visceral fat.
Similarly, during skeletal development, chondrocytes from MSD mice suffer from a severe lysosomal storage defect and display a defective autophagosome digestion leading to a defect in energy metabolism and to cell death.
The calculated activation energies for different diameters suggest a preferential diameter range for optimum hydrogen storage in defective boron nitride nanotubes.
The plausible explanation could be recent contamination of the water distribution system by human and/or animal feces due to defective sewage lines and storage tanks.
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