Sentence examples for defective step from inspiring English sources

Finally, the obtained complementary results will be discussed and an explanation of the failure mechanism will be presented as the root cause issue, allowing defining the defective step in production process.

To identify a defective step, we used an assay system in which we can visualize the initial kinetochore-microtubule interaction in a stepwise manner [17].

Similarly to our previous study in non-diabetic CAD patients, our results of diminished transfer of unesterified cholesterol to HDL in T2DM + CAD also point to a second defective step in unesterified cholesterol metabolism, now involving the entry of unesterified cholesterol from lipoproteins in the HDL fraction.

These data suggest that the loss of translation activity in the loop 3 sequence mutants is imparted by at least one defective elongation step at or preceding tetrapeptide formation.

The functional genomics approach together with the establishment of defective biosynthesis steps in humans and generation of yeast and plant mutants in sterol biosynthesis enabled the elucidation of structural genes for the individual enzymes in sitosterol, ergosterol, and cholesterol formation.

So we further tested whether these mutants might be also defective in the step that follows DNA binding, i.e., synapsis and DNA cleavage.

Together, our data suggest that the elimination of defective stem cells in the postimplantation epiblast follows sequential steps.

Dietary supplementation of PUFAs, such as γ-linolenic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, which bypass the defective or dysfunctional steps of the biosynthetic pathway has been found to significantly alleviate the symptoms of the disease.

Much of our understanding of the mechanisms of HR is based on physically monitoring double-strand break-induced recombination in Saccharomyces cerevisiae and analysis of mutants defective for different steps in the pathway.

Physical interaction of HIV-1 IN and RT has been noticed [15], [36], [40], [41] and certain mutations of IN result in viruses defective in early steps of reverse transcription [36], [40].

Much of what is known about the sterol pathway in Arabidopsis has been worked out by complementing yeast strains defective in specific steps of sterol biosynthesis with the Arabidopsis ortholog [20].