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These age-related defects in T cells are the major contributor to the defective responses to vaccines that develop with age 15, 16, a process that imposes a significant medical burden upon older persons 17.
As we have seen, the paradigmatic natural law view holds that there are some general rules of right that govern our pursuit of the various goods, and that these rules of right exclude those actions that are in some way defective responses to the various basic goods.
In cells where p53 or p21 function is defective, responses to genotoxic stress are also impaired.
Ex vivo events can be linked to defective responses through βc-associated receptors.
These cells had typical characteristics of immature B cells with shorter life span and defective responses to BCR stimulation.
It also indicates that mtDNA damage might be a common pathological condition in a subgroup of FGD patients with defective responses to DNA damage [102].
Similar(44)
However, lack of ATM causes not only a defective response to DNA-DSBs, but also a defect in regulating cellular responses to oxidative stress [7,17].
In this type of artifact, defective response is quite similar to that of a non-defective one.
How, though, are we to determine what counts as a defective response to the goods?
In the normalization technique, every point on the defective response curve is scaled by a fixed value.
A defective response to clopidogrel or aspirin treatment may concern up to 30 or 40% individuals, respectively [257 259].
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