Sentence examples for defective regulation from inspiring English sources

They found that Apoe −/− and APOE4 mice, but not APOE2 or APOE3 mice, had severe BBB defects that were caused by defective regulation of the levels of cyclophilin A (CypA).

Based on our results, we propose that the key defect underlying the hyperphagic behavior in PWS is not defective regulation of energy homeostasis as had been proposed [19], [20], but rather defective control of meal termination.

The distinctive nature of the Hmx1 mutant phenotypes, resulting either from the loss of protein function or defective regulation, is underscored by comparison with the effects of other genes that regulate morphogenesis of the pinna.

It may be that SIRT6 affects transcription at many loci in a tissue-specific manner; the metabolic defect associated with the lack of SIRT6 could represent the net result of defective regulation of multiple genes.

However, both psychosocial and biochemical mechanisms seem to be important causes; the chief biochemical cause appears to be the defective regulation of the release of one or more naturally occurring neurotransmitters in the brain, particularly norepinephrine and serotonin.

Defective regulation of these channels is a prominent characteristic of cystic fibrosis.

Given the plasticity of the CD4+ T cell subsets [ 33], future studies should determine whether the defective regulations of FOXP3+ T cells and Th1/Th17 T cells in lupus patients are functionally related.

Thus, the observed stimulation of glucagon release cannot be explained in terms of defective paracrine regulation and rather suggests that the defect occurs within the alpha cell itself.

The authors suggested that defective growth regulation could not be the primary defect in the initiation of cysts, but rather the relationship between proliferation and cyst formation might be indirect.

To determine a possible role for defective immune regulation in this chronic condition, proinflammatory and anti-inflammatory immune responses to the 70-kd heat shock protein and to lipopolysaccharide were compared in women with and without vulvar vestibulitis syndrome.

This may reflect a heightened response or defective negative regulation in Gαi2-deficient cells.