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Merged hits were regarded as pseudogenes when they encompassed at least two homologous exons of the protein-coding gene and had defective reading frames which preclude translation into polypeptides that meet the minimum structural requirements for functional ABC full-size or half-size transporters.
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We first filtered these reads, and removed 527,878 and 711,299 defective reads for each species, respectively.
First, we filtered these reads and removed the defective reads for each species.
These reads were then filtered, and defective reads were removed for each species.
These elements are in most cases defective, but open reading frames can still be found for the retroviral envelope gene, with sixteen such genes identified so far.
The novel, which is nonlinear, begins with a man discovering that the copy of a novel he has recently purchased and is about to begin reading is defective, a Polish novel having been bound within its pages.
Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation.
Reciprocally, the function of the pre-mRNA splicing machinery involves the reading of histone marks, and defective chromatin regulators may affect splicing [ 94].
Correction of TTN reading frame in patient-specific cardiomyocytes rescued defective myofibril assembly and stability and normalized sarcomeric protein expression.
Though skipping of the LNK pair may break the reading frame, the low abundance of this defective transcript will probably not cause severe loss of overall product activity.
Thus the set of instructions to produce the muscle protein, dystrophin, isn't read in full; this causes the body to produce a defective form of dystrophin that is too short to do its job.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com