Sentence examples for defective proliferation from inspiring English sources

It is the only CDKI associated with normal embryonic development, with loss of expression in mouse embryos leading to defective proliferation in lens and cartilage, and developmental defects in several tissues and increased postnatal lethality (Zhang et al, 1998).

Consistent with this possibility, Cbl-b and Vav1 double knockout mice have been studied by Krawczyk et al[29], who reported that Cbl-b inactivation did not reverse the defects in thymic development in Vav1-/ mice but did reverse defective proliferation of peripheral T cells.

Moreover, cyclin D1, D2 or D3−/− mice displayed tissue specific phenotypes including defective proliferation [81] [83].

Therefore, we decided to investigate whether down-regulation of Bmi-1 contributes to defective proliferation of Atm-/ NSCs.

Our data suggests that p38 is a central player in the defective proliferation of Atm-/ NSCs induced by oxidative stress.

Finally, Cdc42−/− thymocytes display a defective proliferation, in response to anti-CD3/-CD28 stimulandon, aberrantranTCRCR signaling.

To circumvent the possibility of defective astrocyte proliferation hence affecting microglia proliferation, the mixed glia cultures were set up by mixing either G1 mTerc−/− or G4 mTerc−/− with DsRed postnatal brain tissue in a ratio of 1 10.

These results suggested that SERPINB2 could serve as a sensitive marker for predicting toxic responses such as defective cell proliferation or differentiation to various chemicals.

Stat3 MuSCs from both mutant lines were defective in proliferation.

HDAC4 inactivation leads to defective SC proliferation, muscle regeneration, and aberrant lipid accumulation.

The significant delay in the latter stage of wound healing suggested a defective cell proliferation.