Sentence examples for defective processing from inspiring English sources

Considering that a decrease in Mms4 phosphorylation leads to Rad51-dependent slow growth defects in combination with sgs1Δ and to defective processing of persistent SCJs in late G2/M, we conclude that Mms4 phosphorylation in mitosis potentiates its resolution activity in vivo, similarly to what has been proposed in vitro (Matos et al, 2011; Gallo-Fernandez et al, 2012).

We hypothesized that the severe developmental and neurological problems in CS may be a consequence of defective processing of endogenous oxidative DNA lesions.

Guda K, Claffey KP, Dong M, Nambiar PR, Rosenberg DW. (2003) Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.

These abnormal processing events may account for the low levels of mature mt-like RNAs in vivo and are most likely related to defective processing by RNase P.

A large number of studies implicated defective processing of APP and formation of neurotoxic Aβ oligomers as a main cause of synaptic dysfunction in AD [4], [35].

These aberrant PS-1 processing steps in HPRT-deficiency LND may provide useful clues to previously unsuspected purinergic contributions to defective processing of APP as found in familial Alzheimer's disease [25], [26], [31], [33] [35].

Very low levels of CFTR are found in class V mutations, in which splicing defects lead to defective mRNA processing.

Thus, a combination of persisting defects, detected earlier, as well as cell death, defective proinsulin processing and insulin resistance, cause the exacerbation of the phenotype in old age.

In vitro, ATG (BECN1 or ATG7) knockdown compromised MEC-mediated apoptotic body clearance in association with decreased RAC1 activation, thus confirming that, in addition to the defective phagocytic processing reported by other studies, ATG protein defects also impair dead cell engulfment.

Defective Lamin processing, associated with DNA damage, is present in VSM from old individuals, indicating processing defects may be a factor in normal aging.

To further understand the nature of the defective miRNA processing after OTA toxicity, we determined the expression of key regulators of miRNA processing: Drosha, Dicer1 and DRCG8.