Sentence examples for defective presentation from inspiring English sources

We conclude that the defective presentation of B16.OVA tumor antigen by tumor-infiltrating dendritic cells and in the tumor-draining lymph node is not due to the presence of "natural" CD4+CD25+ Treg.

RANKL-deficient mice have defective osteoclastogenesis due to defective presentation of RANKL, an essential signal for osteoclastogenesis, to osteoclast precursors [ 12].

This reduced invasion can result in a defective presentation of bacterial antigens through a Major Histocompatibility Class (MHC) I pathway [ 21] because these antigens are not present in sufficient levels in the intracellular compartment.

There is clear in vivo evidence that ERAP1 is important in HLA-class-I-mediated immunity, with ERAP1-/ mice being shown more prone to infection with Toxoplasma gondii, a vacuolar parasite, due to defective presentation of parasite antigen by the murine HLA class I system to CD8 T cells [ 48].

In the early phase of sepsis, the overwhelming inflammatory response is initiated after microbial infection [59], while the late phase is characterized by T cell hyporesponsiveness and defective antigen presentation [60, 61].

In HIV it has been suggested that defective antigen presentation is a factor in immune deficiency [12].

Therapy targeting IL-6 might support the defective antigen presentation in MM patients.

Increased levels of CSFs following systemic administration may also have beneficial effects by helping to reverse the defective antigen presentation and tumoricidal activities that are found in mononuclear phagocytes isolated from cancer patients (Kleinerman et al, 1980).

Thus, it seems plausible that the observed down-regulation of IFN-γ gene expression in sepsis is indicative of defective antigen presentation by APCs such as monocytes, rather than an intrinsic T cell defect.

These changes point to defective antigen presentation, decreased cytotoxic T cell function and the suppression of unconventional regulatory T cells, such as the resident TCRγδ or TCRαβ CD8+ intraepithelial lymphocytes [ 94].

2, 3 The generation of antiviral CD8+ T-effector (Teff) cells is suboptimal in the liver, in part, because of defective antigen presentation and a skewed CD4+ Th1/Th2 cell balance resulting in diminished T-cell proliferation, decreased production of proinflammatory cytokines, and reduced expression of cytolytic effector molecules.