Luxation of the patella or other defective positions of joint structures was not observed.
During the course of the disease, the skin became generally inflexible and firm, apparently encasing the patient and resulting in mounting flexion contractures and defective positions of the joints.
Nde1−/−Lis1+/− progenitors were also found to be defective in positioning the metaphase chromosomes, another phenotype of failed mitotic spindle function.
However, the defective neuronal positioning of mTor loxP/loxP; Nestin-cre brains could be induced indirectly by abnormal regulation of neural progenitors.
For example, ANC-1 mediated actin-LINCs in C. elegans have been identified as mitochondrial scaffolds, where ANC-1 mutants display defective mitochondrial positioning (Ref. 53).
Finally we examined how the reduced CD4+ DC frequency and defective DC positioning in EBI2-deficient mice affected CD4 T cell and T-dependent B cell responses.
In addition, it was indicated that enhanced immunity in CCR7−/− mice is caused by the defective lymph node positioning of Treg cells and the consequent impediment of the suppressor function [23].
Factors such as unrepaired DNA damage, faulty mitotic spindle organization, functioning or positioning, defective septum organization or perturbations in mitotic checkpoints may affect the final DNA content of the cells.
The naturally formed porous structure accurately represents the internally defective geometric shape and position.
Knee injury (ACL injury, meniscal injury, cartilage damage) leads to functional instability, i.e., a sudden loss of control of the injured joint in a weight-bearing position, and defective neuromuscular function (e.g., reduced strength and functional performance, differences in movement and muscle activation patterns, proprioceptive deficiency, and impaired postural control) [ 12, 16, 26].
