Sentence examples for defective orientation from inspiring English sources

We can exclude that this defective orientation results from a defect in the generation of planar polarity cues at the clone border since both fz RNAi) (Fig. 4B,B') and Vang mutant SOPs (Fig. 4D,D') appear to orient their polarity axis relative to the border of the Vang and fz RNAi) clones, respectively.

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Our results and other studies showed that Sdc4 and Vangl2 are both expressed in the cochlea (Torban et al., 2007) and in the epidermis (Gallo et al., 1996; Murdoch et al., 2003; Devenport and Fuchs, 2008), supporting the defective orientation of sensory hairs in the cochlea and delayed wound healing observed in Sdc4 Lp/+/lacompound2 Lp/+ comicend mice.

Transfection of C2 but not C2 M-CBR3 rescued defective AM orientation and 3D morphogenesis of PTEN-deficient Caco-2 cultures.

Furthermore, tissue architecture disorganization, a typical feature of malignant transformation, might occur due to defective spindle orientation [ 12, 14].

To further elucidate the origin of the defective embryo orientation at post-implantation stages, we performed detailed histological examinations coupled with immunofluorescence staining of E-cadherin or cytokeratin (epithelial markers) at the pre-implantation and initial implantation stages.

We have generated GSC clones of various genotypes examined in this study to show that defective COC/spindle orientation results in a higher frequency of symmetric stem cell division (added as Figure 6).

In HeLa cells, WDR62 accumulates in the centrosome or nucleus in a cell cycle-dependent manner; siRNA knockdown of WDR62 in cortical progenitors decreased their proliferation, caused defective spindle orientation, and reduced the centrosome integrity, displacement from the spindle poles and late mitotic development [ 31].

To gain further insight into the molecular requirements for this checkpoint, we investigated other mutants known to be defective in centrosome orientation.

We also found that ipla-1 mutants were defective in spindle orientation.

We found that the apc1 mutant showed only a 1.7-fold difference in centrosome and spindle misorientation (Figure 4C), indicating that the apc1 mutant is partially defective in the centrosome orientation checkpoint.