These findings also support the notion that defective autolysis is another meta-phenotype, like chaining, that results from the alteration of one or more several possible pathways.
Furthermore, the significant reduction of IL-2 and IFNγ with a trend towards decreased antigen-specific proliferative responses in the egg+IgEhi subgroup corresponds with the notion that defective IL-2 production is associated with advancing HIV immunodeficiency [ 6].
In line with this notion, treatment of APC defective Min mice [5] with cyclooxigenase-2 (COX2) inhibitors results in a transient suppression of polyposis [6], [7], an observation that parallels the response of colon cancer patients to similar treatments [8].
However, when cell cycle checkpoint defects are combined with defective DSB repair, the impact is more than additive, consistent with the notion that cell cycle checkpoint arrest enhances the opportunity for DSB repair.
The notion that a building is defective unless the spaces provided are adequate and appropriate for their intended usage would seem obvious.
Cleaver was then searching for mammalian cell lines that were defective in excision repair, and his intuitive notion that XP individuals might be sunlight-sensitive and prone to cancer because they were genetically defective in excision repair proved to be correct25.
In agreement with this notion, Dnmt2 mutant zebrafish showed defective liver, brain and retina development [15].
Consistent with this notion, WRN-depleted cells show defective synthesis at the lagging strand of sister telomeres perhaps due to the failure to resolve these structures at telomeres [ 23].
Moreover, the authors of this study present NF-κB activation assays with NEMO mutants defective in ubiquitin binding, which support the notion that binding of two di-ubiquitin molecules to NEMO is physiologically important.
This is consistent with the notion that B cell tolerance is generally defective in NZB/W mice [17].
