Translation then switches from the defective message to a short open reading frame on tmRNA that tags the defective nascent peptide chain for degradation.
Expression of FH-Ago2Y529F in endogenous Ago2-depleted cells resulted in defective derepression of miRNA-targeted messages in RAW 264.7 cells whereas repression in cells expressing a phosphomimetic mutant of Ago2, FH-Ago2Y529E, remained unaffected with LPS stimulation (Fig 3E).
Translation of an mRNA that lacks a stop codon stalls the ribosome at the end of the message, and produces a defective polypeptide that may be toxic to the cell.
We then extend our study to the multiple defective sensors detection by modifying appropriately the message exchange protocol and the decoding procedure.
But in his veto message, Mayor Bloomberg called the bill defective, saying, "It would enact legal requirements that conflict with, and would be pre-empted by, those established elsewhere in state law".
The messengers with the most money and most concision are the medical and scientific communities supported in part by profitable genetic testing companies, all touting the same compelling message: people with Down syndrome are defective.
Nothing a bully ever says is enrobed in truth because the core of their message is that their target is defective, less than, and has somehow earned the world's scorn by being 'different.' Their vitriol usually masquerades as labels such as you're too tall, short, fat, thin, black, nerdy, or brilliant.
We first consider networks with one defective sensor and determine the minimal number of linearly independent messages needed for its detection with high probability.
"It's effective in combating the messages that are coming from plastic surgeons, saying 'You're defective if you don't have a child-like [vulva].' Only about 5% of the casts meet that 'perfect' ideal.
If your defective mobile phone still has the ability to make phone calls and receive text messages, dial the star key, the numbers "639," then enter the pound symbol.
