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It seems more plausible to suggest that the agent does participate in such cases, but in a defective manner.
No doubt, those who support coercive laws that require a religious rationale might do so in an insular, intransigent, irrational, or otherwise defective manner.
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For example, if the operation normally requires replacement of 10 units of a certain component each week, you will assume that 2 of those 10 ordered units may be defective in some manner and could slow production.
Even though a plethora of diseases arises from defective cytoplasmic proteins, the manner in which these proteins are recognized and destroyed has been enigmatic.
All of the stocks of ΔgL used in this study were confirmed to be spread defective in vitro in this manner.
The mechanism of action of colchicine remains incompletely understood, but colchicine binds to tubulin and evidently modulates neutrophil adhesion, mobility, and cytokine release in a presumably rather specific manner in patients with defective pyrin variants [ 20, 21].
Figure 2A shows that IFNγ can induce the upregulation of frataxin in frataxin-defective fibroblasts, in a dose-dependent manner.
It may be that SIRT6 affects transcription at many loci in a tissue-specific manner; the metabolic defect associated with the lack of SIRT6 could represent the net result of defective regulation of multiple genes.
Another possibility for the lack of a CPA6 knockdown phenotype may be the involvement of other genes, acting in a compensatory manner in the zebrafish, or defective in reported cases of Duane syndrome but yet undetected.
The percentage of severely defective embryos increased in a dose-dependent manner upon increasing the amount of injected RNA (Fig. S6B).
We present the hypothesis that huntingtin can dynamically communicate between the cytoplasm, nucleus and primary cilium, in a signaling-dependent manner, and that this is defective in HD.
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