Combined with drastic quality control problems, notably a defective line of monitors and some highly publicized combustible portable computers, these failings brought an end to Spindler's reign in early 1996 with the appointment of Gilbert F. Amelio.
Concentrations of HSL ranging from 10 to 50 µM failed to induce substantial increases in intracellular calcium in C38 and IB3-1 (data not shown), whereas at concentrations over 100 µM, Δ[Ca2+]i rose significantly within minutes for the CFTR defective line IB3-1, but not the corrected line C38 (Figure 3A).
Mutants with defective LinE formation display a strongly reduced capability of DSB formation (Cervantes et al. 2000) and genetic recombination (Wells et al. 2006).
We analyzed oocyte nuclei in region 3 of the germarium in both wild-type and SC-defective lines.
The differential toxicity of the 2-amine (3) in the NER-defective line (ratio of AA8/UV4 IC50 values in Table 2) indicates that it is a DNA alkylator (like the 4-hydroxylamine, (4), but the lower ratio (7.1 vs 63) suggests that it may form monoadducts rather than crosslinks.
In order to accurately compare sensitivities to ACNU or TMZ in the repair defective cell lines, the relative D50 values were normalized using the D50 value of the parental cell lines.
Second, BRCA1- and BRCA2-defective cell lines show defects in DSB repair by homologous recombination [ 12, 14].
TOKYO — Toyota will fix about 1.7 million vehicles globally in two separate recalls over defective fuel lines and high-pressure fuel pumps, the Japanese automaker said Wednesday, drawing renewed attention to the quality of the company's products.
Both simulation and experimental results on defective interconnect lines show maximum delays for opens located at intermediate positions provided that the resistance of the open is on the order of the on-resistance of the driving transistor network.
Kinet, N. Kitamura, H. Stenmark and M. Zerial for generous access to antibodies and Drs. J. Zhang and R.P. Siraganian for providing the Syk defective cell lines.
Studies of DNA-repair defective cell lines have shown that various proteins implicated in nucleotide excision repair (NER), homologous recombination (HR), translesion DNA synthesis and Fanconi anemia (FANC) participate in the detection and repair of ICLs [4], [5].
