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Combined with drastic quality control problems, notably a defective line of monitors and some highly publicized combustible portable computers, these failings brought an end to Spindler's reign in early 1996 with the appointment of Gilbert F. Amelio.
Concentrations of HSL ranging from 10 to 50 µM failed to induce substantial increases in intracellular calcium in C38 and IB3-1 (data not shown), whereas at concentrations over 100 µM, Δ[Ca2+]i rose significantly within minutes for the CFTR defective line IB3-1, but not the corrected line C38 (Figure 3A).
Mutants with defective LinE formation display a strongly reduced capability of DSB formation (Cervantes et al. 2000) and genetic recombination (Wells et al. 2006).
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The differential toxicity of the 2-amine (3) in the NER-defective line (ratio of AA8/UV4 IC50 values in Table 2) indicates that it is a DNA alkylator (like the 4-hydroxylamine, (4), but the lower ratio (7.1 vs 63) suggests that it may form monoadducts rather than crosslinks.
We analyzed oocyte nuclei in region 3 of the germarium in both wild-type and SC-defective lines.
RT-PCR for BNIP3 band resulted in a much more intense band in the pVHL defective cell line compared to the pVHL intact cell line (Fig 2).
For example, the BRCA defective cell line HCC1937 was highly sensitive to cisplatin and V158411 whilst the ovarian cell line SKOV-3 was equally sensitive to V158411 but 8-fold more resistant to cisplatin than the HCC1937 cell line.
C1R-A2 is a class I defective cell line transfected with HLA-A2 (Zemmour et al, 1992) and C1R-A2/MC1R is the same line transfected with the MC1R gene.
One record was defective; a line of one poem was incompleted.
This paper proposes a new method to detect all possible corrections from a defective product line model.
Each of these patient's somatic alleles apparently benefited from a proliferative advantage relative to the defective germ line allele at a specific stage of thymocyte development.
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