Knocking down such genes not only blocks autophagy but also renders apoptosis defective, making the interpretation of autophagic roles unreliable.
This interpretation of defective loss sensitivity in the gifted adolescents might account for the stereotypical portrayal of emotional maladaptation of gifted adolescents as compared to average adolescents [13], [14].
Thus, for an in-depth understanding of defect engineering, clearly, theoretical methods are needed as an additional tool to predict the relative stability of potential defective structures and to support the interpretation of spectroscopic results.
Consistent with these interpretations, mice that are genetically defective for p53 and/or p16INK4a, which are critical for mediating senescence, suffer exacerbated fibrosis and delayed resolution of fibrosis in response to CCl4-induced injury.
Allison Hayward, vice president for policy at the Center for Competitive Politics in Washington, a group that supports efforts to ease campaign regulations, called them "defective instructions" in a statement, saying that the interpretation ignores legal precedents that define contributions more narrowly.
However, this interpretation neglects the possibility that the defective silencing observed is due to Epe1 overexpression rather than Epe1 activity.
It is our interpretation that Ptch1Δ2PY fails to exit cilia because of defective endocytosis.
Again, however, the interpretation of the kinetic behavior of the ATP-hydrolysis defective mutants should be straightforward, given the model and the nil turnover relative to the dissociation time; consequently these results also need to be provided.
Interpretation of these results is complicated, however, by the possible contribution of defective p14ARF (Huot et al., 2002; Sviderskaya et al., 2003; Brookes et al., 2004), which is known to confer a growth advantage when silenced (Voorhoeve & Agami, 2003).
* p ≤ 0.05 ** p ≤ 0.01 *** p ≤ 0.001 For any analysis of individuals with defective genes there are important considerations related to the choice of accurate controls and the adequate interpretation of the data.
