Sentence examples for defective interactions from inspiring English sources
Introduction of point mutations at the Arg120 in the interactive sequence of αB crystallin caused defective interactions with the IFs resulting in destabilized IF networks, cataract and desmin-related myopathy [24].
The mathematical approach to model the (cooperative versus defective) interactions is usually tackled under the general framework of evolutionary game theory through diverse social dilemmas [5].
The sequence and timing of episodic killing of GPT neurons recruit distinct levels of defective interactions.
Mutations in GATA4 may lead to defective interactions with NKX2-5, leading to congenital heart diseases [ 8].
Fras1 deficiency causes defective interactions between the bud and mesenchyme, correlating with disturbed expression of key nephrogenic molecules.
Finally and importantly, co-immunoprecipitation experiments showed decreased binding between NQO1 and p53 in SDHx variant-positive patient cells compared with controls (Fig. 3D), suggesting that the loss of p53 is indeed caused by defective interactions between NQO1 and p53.
Our results demonstrate that BubR1Δ432 484, which cannot interact with Bub1 and localize to kinetochores, has a strong defect in kinetochore microtubule attachment that correlates with a defective interaction with PP2AB56.
The defect associated with pol3-ct could result from a defective interaction between Pol δ and a protein involved in recombination.
Also, study of the CFTR interactome has led to elucidation of the molecular defect of S13F- CFTR [ 41] as relating to defective interaction with filamins, which anchor plasma membrane CFTR to the actin cytoskeleton [ 41].
We asked if the defect of the BubR1Δ432 484 mutant in supporting kinetochore microtubule attachment correlated with a defective interaction with PP2AB56.
Therefore, we hypothesize that we may select more druggable targets for the ASDs by enriching for defective interaction networks defined by gene families.
