Long-term survivors of ALL in childhood and adolescence will have defective bone integrity, reflected in reduced network connectivity and increased maximal hole sizes on pQCT.
As shown in Figure 2B, five isolates from complementation groups 1, 2, and 3, including mac33, mac38, mac40, mac42, and mac43, exhibited defective cuticle integrity, suggesting that these mutants carry genetic lesions affecting C. elegans cuticle formation.
49 50 Detection of defective bone integrity, associated with inadequate mineralisation and abnormal architecture, will prompt the exploration of a role for bisphosphonates to enhance bone health and thereby minimise the risk of osteoporosis and debilitating/life-limiting fractures.
However, their uncontrolled production is detrimental to cell function as they damage a variety of biomolecules such as lipids, amino acids, carbohydrates, protein, and DNA and adversely affect sperm function [ 8] due to DNA damage [ 9, 10], reduced motility [ 11], and defective membrane integrity [ 12, 13].
Whereas global deletion of Mef2A or -D demonstrates little to no effect on embryonic myogenesis (Potthoff and Olson 2007), skeletal muscle-specific deletion of Mef2C causes neonatal lethality due to defective muscle integrity and sarcomere formation (Potthoff et al. 2007a, b).
Platelet endothelial cell adhesion molecule (PECAM) antibody staining was reduced in vascular endothelium, and also revealed disordered cell arrangements and thinner walls, implying defective blood vessel integrity in Aga2 severe hearts (Fig. 1D).
The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis.
In cells with defective Leo1 Paf1, only the integrity of the IR boundaries was compromised; thus, the surrounding euchromatin may invade into the pericentric region of otr1R lacking tRNAs.
