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Cancer cells are well known to be the metabolically streamlined cells in which many metabolic pathways become defective in comparison to their normal cell counterparts.
The D211N mutant enzyme pyrophosphorolysis activity also improved proportionately with longer primers compared to the 14-mer primer but was still defective in comparison to WT (Fig. 4C and 4D).
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Since we see increased levels of DSBs in irs1SF cells in combination with downregulation of RAD51-mediated HR repair, we would expect that DRB following UV treatment would have a stronger sensitising effect on HR defective cells in comparison to the wild type cells.
PVD2 animal caps displayed defective healing in comparison to controls and lost their integrity when they reached neurula stage (stage 14).
We observed two major defects during the formation of the infective filaments in strains defective in septins: the filament elongation was retarded in comparison to wild-type strains, and a higher proportion of the cells grew in a bipolar manner.
TLR4 defective mice (C3H/HeJ) showed greater susceptibility to Mtb infection in comparison to wild type mice [ 63], but these mice have been shown to display greater resistance than wild type models upon exposure to low dose Mtb [ 51].
These data suggest that this new method for the generation of large quantities of replication-defective HPV pseudovirions is a significantly more efficient method in comparison to the preparation of HPV pseudovirions by in vitro assembly.
It was found that Ca, Co and Fe doped and defective graphene nanosheets show much higher affinities to H2S molecule in comparison to pristine graphene.
However, 10 of the mutants (designated AM 1 10, meaning Adhesion or invasion defective Mutants) presented a higher than 50 % reduction in adherence in comparison to the adherence observed in the parent strain (Fig. 2).
The defective MIL-100(Fe) showed a marked increase in selectivity to -isopulegol in comparison to the native material, which is a typical behavior of a Lewis acid.
Particularly, during growth on glycerol in comparison to growth on the previously analyzed carbon sources (Kaddor and Steinbüchel 2011), mutants defective in the putative ptsMHI operon accumulated less PHB than the wild type.
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