Sentence examples for defective gene expression from inspiring English sources

Aberrant methylation is a central feature of carcinogenesis and causes defective gene expression, faulty condensation and chromosomal instability and is a hallmark of cellular defenses acting to silence foreign DNA.

However, we found a decrease in the levels of GM1 and GM2 gangliosides in PGC-1β KO samples which correlates with defective gene expression of enzymes regulating this pathway.

Aberrant methylation is a central feature of carcinogenesis; it causes defective gene expression, faulty condensation and chromosomal instability, and is a hallmark of cellular defenses acting to silence foreign DNA.

On the other hand, heterozygosity for a defective PDX1 gene leads to defective preproinsulin gene expression [7] and abnormal insulin secretion [9] in mice and to maturity-onset-diabetes of the young 4 (MODY4) in man [6].

This unbalance could lead to higher hydrogen peroxide production, which may concur to oxidative stress causing defective insulin gene expression due to modification of critical factors that modulate the insulin promoter.

Exposure of pancreatic islets to oxidative stress causes defective insulin gene expression due to modification of at least two critical factors that modulate the insulin promoter : PDX-1 [22] and c-Myc [23].

Numerous studies have implicated PDX-1 and MafA, two transcription factors that are important for insulin gene transcription, in the defective insulin gene expression in β-cells caused by chronic exposure to supraphysiologic concentrations of glucose [17], [18], [19], [20], [21], [22], [23].

Furthermore, both hyperglycemia and hyperlipidemia are associated with induction of oxidative stress in β-cells, which in turn causes defective insulin gene expression and increased apoptosis.

Increase in oxidative stress causes a reduction binding of Pdx1 and MafA to insulin gene in pancreas, which in turn results in defective insulin gene expression and hormone secretion [ 42, 48].

Since RNMTcat is defective for supporting gene expression we investigated whether it is required for supporting cell proliferation.

In addition, both a defective DNA-repair gene expression signature as well as 53BP1 staining indicated that normal adjacent tissue associated with triple-negative breast cancer had enhanced DNA repair compared with normal adjacent tissue from women with ER+ or Her2+ breast cancer.