Sentence examples for defective function from inspiring English sources

Pathophysiology The motor abnormality in achalasia is the result of defective function of the intramural myenteric plexus motor neurons.

Cloning and characterization also open new therapeutic vistas that involve correcting the defective function at the molecular level.

Defective function of the Sonic Hedgehog (SHH) signaling pathway is the most frequent alteration underlying holoprosencephaly (HPE) or its various clinical microforms.

A deficiency of vitamin B12 often causes defective function of the intestine, resulting in indigestion and sometimes constipation or diarrhea.

It is important to address whether the mutational effects observed in vivo have resulted from the defective function of some specific factor that interacts with the arrest site-distal region of MifM.

The pathogenesis of obstructive sleep apnea hypopnea syndrome (OSAHS) is summarized as the narrow anatomic structure of upper airway (UA) and the defective function of UA dilator muscles.

The circadian rhythms of hormones and cytokines in CIA rats may be reset due to the defective function of the HPA axis.

It contends that Knight Capital failed to remove a defective function in one of its routers that was used to execute orders that day.

Likewise, defective function and/or expression of Wiskott-Aldrich syndrome protein, a canonical regulator of actin nucleation through the Arp2/3 complex and an activator of SRF, could release the growth-control machinery by affecting PTEN and p53 expression in the myeloid malignancies that arise in affected WAS patients.

Furthermore, this defective function of natural regulatory T cells was associated with their decreased IL-10 expression, disease severity, and could be reversed by oral corticosteroid therapy.These results provided the first evidences of impaired induction of tolerogenic dendritic cells mediated by natural regulatory T cells in human allergic asthma.

Alessandro Luciani [ 73] demonstrates that the generation of an oxidative stress induced by CFTR-defective function leads to protein inhibitor of activated STAT (PIAS) y-mediated TG2 SUMOylation and inhibits TG2 ubiquitination and proteasome degradation, leading to sustained TG2 activation.