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Because the majority of mis-segregation results in one mis-segregated chromosome per division, this suggests that the large range of chromatid numbers was the consequence of multiple defective divisions.
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H3f3b knockout (KO) mice exhibit a semilethal phenotype traceable at least in part to defective cell division and chromosome segregation.
We addressed whether the stability of ERMES-marked mitochondrial constriction sites is a consequence of defective mitochondrial division in gem1Δ cells by examining the behavior of the division machine, labeled with Dnm1-mCherry, over time.
Introduction of the ethylene-insensitive ein2 mutation partially rescues defective cell division, localization of PIN proteins, and vascular strand development.
The use of siRNA specific for VRK1 caused a defective cell division in a colon tumor cell line [19].
That is exactly what is observed (Fig. 5) in an ftsZ mutant which filaments due to its defective cell division apparatus.
Another possibility is that defective cell division plays a role.
VMP1 has thus far not been implicated in relation to defective cell division.
The black lines indicate mean ± SEM. (G ) MELK inhibition induces defective cell division.
Given that the microscopic phenotypes pointed toward defective cell division, we sought to assay for the expression in the mutant of several key regulators of the cell cycle.
We propose that the abnormal motility and defective neuronal division observed in Lis1 RNAi [ 21] emerge from a delay in the multipolar stage.
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