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The overlap is most pronounced in the limb developmental defects, which likely originate in defective development of the apical ectodermal ridge or maintenance of stem cells of this specialized epithelium.
High ROS levels can be indicative of defective antioxidant machinery or an inhibition/block in the electron transport chain, and elevated ROS and impaired oxidative phosphorylation have been linked with defective development and meiotic spindle defects.
Ciliary defects have been associated with defective development in the nematode Caenorhabditis elegans [ 3] as well as a growing list of devastating human genetic disease conditions collectively called ciliopathies, including polycystic kidney disease (PKD), Bardet-Biedl syndrome (BBS), Alstrome syndrome, Joubert syndrome, Meckel-Gruber syndrome, and primary ciliary dyskinesia [ 4, 5].
The congenital, but not hereditary, T-cell deficiency disease called DiGeorge syndrome arises from a developmental defect occurring in the fetus that results in the defective development of the thymus.
"This is India's defective development".
This is such a new field of study that up to now scientists have concentrated on identifying the chromosome abnormalities associated with disease and defective development, rather than on speculating about their causes.
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However, there is more and more evidence that the proper development of tissue and organisms strongly depends on mechanical influences and that disorders in the mechanosensing machinery of the cell are closely related to defective developments and diseases.
Successfully injected embryos were distinguished on the basis of the red fluorescence (insets) and classified on the basis of morphology into 'severely defective' (blocked development), 'defective' (altered development) or 'normal'normal
Together, these observations suggest that our Dlk1conditional mutation leads to defective muscle development and postnatal growth retardation.
Besides testicular teratomas, mouse strains that spontaneously develop ovarian teratomas as result of defective oocyte development also were described (Andrews 2002).
Interestingly, neuromuscular junction (NMJ) maturation defects precede lower motor neuron connectivity abnormalities in mice, indicating that defective synapse development may play a role in pathology (13).
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