More precisely, OTB filters have been used for all radiometric corrections (denoising, defective pixel detection and correction, quality mask and TOA conversion) and resampling operations.
A developing therapy of cystic fibrosis caused by the ΔF508 mutation in CFTR employs correction of defective CFTR chloride channel gating by a 'potentiator' and of defective CFTR protein folding by a 'corrector'corrector
Radiometric correction rectifies defective columns and missing lines and reduces the non-uniformity of the sensor response among detectors.
They include replacing the mutated gene with a functional candidate gene (gene replacement) or repairing the defective gene by targeted correction and exon skipping (gene repair).
It follows, therefore, that MDM2, PP2A, and CDC25C constitute therapeutic targets for the correction of defective erythropoiesis in patients with del 5q) MDS.
In spite of recent successes in site-specific correction of defective gene sequences, the focus of most gene therapy strategies to date is on gene addition rather than gene replacement (Urnov et al, 2005).
For example, the in vitro correction of defective genes prior to transplant could be used either to restore male fertility or to prevent transmission of mutant alleles associated with genetic diseases.
Interestingly, Indjeian and Murray (2007) demonstrated the existence of a bias to sister kinetochore biorientation in the sgo1-100 mutant, which is defective in the error correction process (Indjeian et al., 2005).
Moreover, the rescue of the CPVT-disease phenotype in a patient-specific iPSC-based system by dantrolene provides the first evidence that, as in the case of malignant hyperthermia, correction of defective inter-domain interaction within mutated human RYR2 may represent an effective novel causal therapy for CPVT1.
Likewise correction of the defective genes by gene therapy has also been tried.
