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Evidence has been obtained that a defective coordination between the centrosome cycle and the DNA replication cycle leading to abnormal, often tripolar, mitoses and highly unequal segregation of chromosomes between daughter cells is crucial for the generation of high-degree aneuploidy seen in the A-tumours (Kronenwett et al, 2005).
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Consistent with these histological changes, Sun1 −/− and Sun1 −/−Sun2 +/− mice exhibited defective motor coordination.
Consistent with the histological findings on cerebellar alterations, Sun -deficient mice exhibit defective motor coordination.
Thus, CDH12 (cadherin 12) and/or DGKB (diacylglycerol kinase, beta) might be candidates for the observed generalized hypotonia and defective motor coordination.
However, some sites almost had no work related meetings which would mean study coordination was defective.
Improper GNP maturation can result in defective foliation, which is associated with defects in motor coordination [6], [7], or in medulloblastoma, the most common childhood brain tumor [8].
This will result in defective movement of the eyes, causing lack of coordination between the two eyes and diplopia, or double vision.
The disease produced serious sequelae such as visual, olphactory, and auditory disturbances, lack of motor coordination, equilibrium disturbance, swallowing difficulties, incontinence, and defective memory.
In chalcogenide glasses, semiconductivity is primarily caused by defective bonds in which a particular atom does not follow its covalent coordination.
Prior to seizure onset, heterozygous mutants are not defective in motor learning or fear conditioning, but do exhibit mild impairment of motor coordination and social discrimination.
Though activation of these key downstream signaling pathways in the absence of TRAF6 autoubiquitination appeared normal, TRAF6-mediated gene regulation involves complex coordination of multiple transcription factor families, leaving the possibility that genetic regulation by TRAF6 K32-518R might be defective.
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